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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling is involved many biological effects that include metabolic processes involving calcium and phosphorous parathormone release, cell growth and regulation of adaptive and innate immunity.
A T > C alteration in the promoter of VDR variant (rs11568820) removes the binding site of the transcription factor Cdx2 just upstream of exon 1. This leads to a smaller protein with decreased transcriptional activity. The F allele is present in high frequency among Asians and Europeans, and in low frequencies in Sub-Saharan Africans.
The findings of this study help us understand how VDR gene polymorphisms modulate the response to dietary supplements containing calcium calcitriol. The carriers of the TaqI and FF genotypes of the FokI polymorphisms have greater transcriptional activation and are associated with higher calcium absorption, a higher bone mineral density, and a reduced risk of breaking. To improve our understanding of the role that these genetic variations play in the supplementation of vitamin D We must study more using a homogeneous design.